{"id":4802,"date":"2020-05-26T15:33:39","date_gmt":"2020-05-26T15:33:39","guid":{"rendered":"http:\/\/ibshypo.com\/?page_id=4802"},"modified":"2020-05-26T16:59:45","modified_gmt":"2020-05-26T16:59:45","slug":"a-noxious-factor-in-the-faecal-stream","status":"publish","type":"page","link":"https:\/\/ibshypo.com\/index.php\/a-noxious-factor-in-the-faecal-stream\/","title":{"rendered":"A Noxious Factor in the Faecal Stream"},"content":{"rendered":"\n<p class=\"has-background has-very-light-gray-background-color\">We have seen how budesonide can restore normal collagen layer thickness.  A remarkably similar effect occurs when the faecal stream is diverted by ileostomy.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><a href=\"https:\/\/doi.org\/10.1016\/0016-5085(95)90332-1\" target=\"_blank\" rel=\"noreferrer noopener\"><img loading=\"lazy\" src=\"http:\/\/ibshypo.com\/wp-content\/uploads\/2020\/05\/image.png\" alt=\"\" class=\"wp-image-4709\" width=\"949\" height=\"492\" srcset=\"https:\/\/ibshypo.com\/wp-content\/uploads\/2020\/05\/image.png 949w, https:\/\/ibshypo.com\/wp-content\/uploads\/2020\/05\/image-300x156.png 300w, https:\/\/ibshypo.com\/wp-content\/uploads\/2020\/05\/image-768x398.png 768w\" sizes=\"(max-width: 949px) 100vw, 949px\" \/><\/a><figcaption><strong>Collagenous colitis and fecal stream diversion J\u00e4rnerot, Gunnar et al. Gastroenterology 1995 Aug;109(2):449-55. <\/strong><\/figcaption><\/figure><\/div>\n\n\n\n<p style=\"text-align:left\" class=\"has-background has-very-light-gray-background-color\">Another study of a patient with severe collagenous colitis confirms that temporary faecal stream diversion restores the mucosal structure but relapses after the ileostomy is reversed.  The authors hypothesise that a luminal toxic agent triggers the onset of CC<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><a href=\"https:\/\/gut.bmj.com\/content\/54\/8\/1126\" target=\"_blank\" rel=\"noreferrer noopener\"><img loading=\"lazy\" src=\"http:\/\/ibshypo.com\/wp-content\/uploads\/2020\/05\/image-7.png\" alt=\"\" class=\"wp-image-4757\" width=\"648\" height=\"297\" srcset=\"https:\/\/ibshypo.com\/wp-content\/uploads\/2020\/05\/image-7.png 648w, https:\/\/ibshypo.com\/wp-content\/uploads\/2020\/05\/image-7-300x138.png 300w\" sizes=\"(max-width: 648px) 100vw, 648px\" \/><\/a><figcaption><strong>M\u00fcnch A, S\u00f6derholm JD, Wallon C, et al  Dynamics of mucosal permeability and inflammation in collagenous colitis before, during, and after loop ileostomy  Gut 2005;54:1126-1128.<\/strong><\/figcaption><\/figure><\/div>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color\">We now look at the possibility that <a href=\"http:\/\/ibshypo.com\/index.php\/collagenous-colitis-and-bile-acid-malabsorption\/\">bile acid could be a noxious factor<\/a>.<\/p>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n","protected":false},"excerpt":{"rendered":"<p>We have seen how budesonide can restore normal collagen layer thickness. A remarkably similar effect occurs when the faecal stream is diverted by ileostomy. Another study of a patient with severe collagenous colitis confirms that temporary faecal stream diversion restores the mucosal structure but relapses after the ileostomy is reversed. The authors hypothesise that a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/pages\/4802"}],"collection":[{"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/comments?post=4802"}],"version-history":[{"count":5,"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/pages\/4802\/revisions"}],"predecessor-version":[{"id":4838,"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/pages\/4802\/revisions\/4838"}],"wp:attachment":[{"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/media?parent=4802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}