{"id":2325,"date":"2019-04-21T12:16:06","date_gmt":"2019-04-21T12:16:06","guid":{"rendered":"http:\/\/ibshypo.com\/?page_id=2325"},"modified":"2019-04-22T15:38:15","modified_gmt":"2019-04-22T15:38:15","slug":"olestra","status":"publish","type":"page","link":"https:\/\/ibshypo.com\/index.php\/olestra\/","title":{"rendered":"Olestra"},"content":{"rendered":"\n<p class=\"has-background has-very-light-gray-background-color\">PBDEs are lipophillic flame retardants, they attach to fat.  Ingestion is via dermal contact, inhalation and food.  I took simple precations to reduce exposure including removing a sofa and foam backed carpet, vacuuming with a HEPA filter and cutting excess fat from food.<\/p>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color\">PBDEs are subject to enterohepatic recirculation. They are extracted by the liver, secreted into the gut via the bile duct and reasorbed.  Cholesterol is reabsorbed in a similar manner and drugs called cholesterol absorption inhibitors are used to lower cholesterol levels.<\/p>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color\">Olestra, a  non-absorbable \u2018fake fat\u2019 used in the USA to make \u2018zero fat\u2019 crisps has been used in clinical trials to <a rel=\"noreferrer noopener\" aria-label=\"eliminate lipophilic toxins (opens in a new tab)\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10481251\" target=\"_blank\">eliminate lipophilic toxins<\/a> including  <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10520643\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\">dioxins<\/a> and PCBs in humans and <a rel=\"noreferrer noopener\" aria-label=\"PBDEs in rodents (opens in a new tab)\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=16910742\" target=\"_blank\">PBDEs in rodents<\/a>.  I imported Olestra baked crisps from the USA consuming 24g crisps (10g Olestra) daily: &#8211;<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><img loading=\"lazy\" src=\"http:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image-28.png\" alt=\"\" class=\"wp-image-2348\" width=\"372\" height=\"311\" srcset=\"https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image-28.png 496w, https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image-28-300x250.png 300w\" sizes=\"(max-width: 372px) 100vw, 372px\" \/><\/figure><\/div>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color\">After six weeks, I became mildly hyperthyroid (difficulty getting to sleep) and had to repeatedly reduce my L-T3 dose form 85 to 30 mcg.  My symptoms were very much improved on a lower dose of liothyroine.  The effect was not gradual, the RTH reduced in steps.  Unfortunately, olestra baked crisps were discontinued in 2015.  My hypothyroidism worsened and my L-T3 requirement increased to 60 mcg.  As well as the higher liothyronine dose my symptoms were worse.  This was the first human trial of olestra for the elimination of PBDEs.<\/p>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color\">I needed to find an <a href=\"http:\/\/ibshypo.com\/index.php\/polydimethylsiloxane\/\">alternative method of eliminating PBDEs<\/a>.<\/p>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n","protected":false},"excerpt":{"rendered":"<p>PBDEs are lipophillic flame retardants, they attach to fat. Ingestion is via dermal contact, inhalation and food. I took simple precations to reduce exposure including removing a sofa and foam backed carpet, vacuuming with a HEPA filter and cutting excess fat from food. PBDEs are subject to enterohepatic recirculation. They are extracted by the liver, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/pages\/2325"}],"collection":[{"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/comments?post=2325"}],"version-history":[{"count":21,"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/pages\/2325\/revisions"}],"predecessor-version":[{"id":2486,"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/pages\/2325\/revisions\/2486"}],"wp:attachment":[{"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/media?parent=2325"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}