{"id":2194,"date":"2019-04-19T22:10:14","date_gmt":"2019-04-19T22:10:14","guid":{"rendered":"http:\/\/ibshypo.com\/?page_id=2194"},"modified":"2025-05-06T16:23:41","modified_gmt":"2025-05-06T16:23:41","slug":"endocrine-disrupting-chemicals","status":"publish","type":"page","link":"https:\/\/ibshypo.com\/index.php\/endocrine-disrupting-chemicals\/","title":{"rendered":"Endocrine Disrupting Chemicals (EDCs)"},"content":{"rendered":"\n<p class=\"has-medium-font-size\">Some background information on EDCs from major international bodies.<br><\/p>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h3>A Talk on endocrine disruptors by leading expert Thomas Zoeller<\/h3>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<figure class=\"wp-block-embed aligncenter is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"UMass Distinguished Faculty Lecture: Professor R. Thomas Zoeller\" width=\"730\" height=\"411\" src=\"https:\/\/www.youtube.com\/embed\/t44UbutlYg4?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen><\/iframe>\n<\/div><figcaption> <br><strong>For those interested in a little more detail this is an  excellent video.  Prof Zoeller is an outstanding scientist, this is  mainstream science.  There are introductions and biography and the talk  begins just after 7 minutes in.  At around 37:10 there is mention of  thyroid disruption with normal blood tests. <\/strong><\/figcaption><\/figure>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h3>Notes on endocrine disruptors from the United States Government &#8211; The National Institute of Environmental Health Sciences (NIEHS) <\/h3>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><a href=\"https:\/\/www.niehs.nih.gov\/health\/topics\/agents\/endocrine\/index.cfm\" target=\"_blank\" rel=\"noreferrer noopener\"><img loading=\"lazy\" width=\"643\" height=\"217\" src=\"http:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image-19.png\" alt=\"\" class=\"wp-image-2222\" srcset=\"https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image-19.png 643w, https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image-19-300x101.png 300w\" sizes=\"(max-width: 643px) 100vw, 643px\" \/><\/a><\/figure><\/div>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h3>World Health Organisation \/ United Nations Environmental Program<\/h3>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full is-resized\"><a href=\"https:\/\/www.who.int\/publications\/i\/item\/9789241505031\" target=\"_blank\" rel=\"noreferrer noopener\"><img loading=\"lazy\" src=\"https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image-17.png\" alt=\"\" class=\"wp-image-2212\" width=\"437\" height=\"625\" srcset=\"https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image-17.png 583w, https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image-17-210x300.png 210w\" sizes=\"(max-width: 437px) 100vw, 437px\" \/><\/a><figcaption> <br><strong>State of the science of endocrine disrupting chemicals &#8211; 2012<\/strong><\/figcaption><\/figure><\/div>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h3> <br>Endocrine experts united in disappointment with European Commission&#8217;s proposed criteria on EDCs <\/h3>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><a href=\"https:\/\/www.endocrine.org\/news-and-advocacy\/news-room\/2017\/endocrine-experts-united-in-disappointment-with-european-commissions-proposed-criteria-on-edcs\" target=\"_blank\" rel=\"noreferrer noopener\"><img loading=\"lazy\" width=\"600\" height=\"159\" src=\"http:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image.jpeg.png\" alt=\"\" class=\"wp-image-2239\" srcset=\"https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image.jpeg.png 600w, https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image.jpeg-300x80.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/a><figcaption> <br><strong>The European Society of Endocrinology (ESE) co-signed a joint letter  with the Endocrine Society (ES) and the European Society for Paediatric  Endocrinology (ESPE) to the European Commission expressing concern with  the proposed criteria for the identification of Endocrine Disrupting  Chemicals (EDCs). <\/strong> <\/figcaption><\/figure><\/div>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p class=\"has-light-green-cyan-background-color has-background\">We can see that EDCs are part of mainstream science.  They have harmful effects on many hormone systems.  This topic is championed by The Endocrine Society, the US NIEHS, WHO, UNEP and the European Society of Endocrinology. <\/p>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p class=\"has-very-light-gray-background-color has-background\">In the topic on RTH we saw how a mutant receptor can bind to the Thyroid Response Element in preference to wild type (healthy) receptor and block hormone action.  Mutant receptors also disrupt hormone action by other mechanisms.  A mutant receptor is like but not quite the same as a wild type receptor.  Endocrine disrupting chemicals are like but not quite the same as hormones.<\/p>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p class=\"has-light-green-cyan-background-color has-background\">Whilst there is great concern about EDCs I know of no studies that select a patient group, identify the EDC that causes their illness and finds a cure.  This is the purpose of the Acquired Resistance to Thyroid Hormone (ARTH) topic. <\/p>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p class=\"has-very-light-gray-background-color has-background\">If we look at the image below we can see that thyroid hormones are present in minute quantities, especially free T3.  T3 has an elimination half-life of about a day.  Many EDCs have much longer half-lives.  For example, if EDC has a half-life of 100 days (not unusual) minute amounts would accumulate up to typical fT3 levels.<br><\/p>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Reference_ranges_for_blood_tests#\/media\/File:Blood_values_sorted_by_mass_and_molar_concentration.png\" target=\"_blank\" rel=\"noreferrer noopener\"><img loading=\"lazy\" width=\"1024\" height=\"147\" src=\"http:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image-22-1024x147.png\" alt=\"\" class=\"wp-image-2271\" srcset=\"https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image-22-1024x147.png 1024w, https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image-22-300x43.png 300w, https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image-22-768x110.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><figcaption><strong>Clicking on the image that pops up will give a close up view.<\/strong><\/figcaption><\/figure>\n\n\n\n<p class=\"has-very-light-gray-background-color has-background\">A number of EDCs affect thyroid function.  Some are such that human exposure is unlikely, others have a short half-life.  Patients are likely to notice the effects of EDCs with short half-lives and take  avoiding action.  We look at EDCs with long half-lives and potential for human exposure, <a href=\"http:\/\/ibshypo.com\/index.php\/polybrominated-diphenyl-ethers-pbdes\/\">polybrominated diphenyl  ethers (PBDEs)<\/a> are the prime candidate. <\/p>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Some background information on EDCs from major international bodies. A Talk on endocrine disruptors by leading expert Thomas Zoeller Notes on endocrine disruptors from the United States Government &#8211; The National Institute of Environmental Health Sciences (NIEHS) World Health Organisation \/ United Nations Environmental Program Endocrine experts united in disappointment with European Commission&#8217;s proposed criteria [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/pages\/2194"}],"collection":[{"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/comments?post=2194"}],"version-history":[{"count":85,"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/pages\/2194\/revisions"}],"predecessor-version":[{"id":7253,"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/pages\/2194\/revisions\/7253"}],"wp:attachment":[{"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/media?parent=2194"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}