{"id":149,"date":"2019-02-26T15:05:39","date_gmt":"2019-02-26T15:05:39","guid":{"rendered":"http:\/\/ibshypo.com\/?page_id=149"},"modified":"2019-04-10T18:31:14","modified_gmt":"2019-04-10T18:31:14","slug":"mangesium-and-nmda-receptors","status":"publish","type":"page","link":"https:\/\/ibshypo.com\/index.php\/mangesium-and-nmda-receptors\/","title":{"rendered":"Magnesium and NMDA Receptors"},"content":{"rendered":"\n<p class=\"has-background has-very-light-gray-background-color\">Magnesium plays a central role in the activation of NMDA receptors.&nbsp; NMDA receptors are triggered after prolonged glutamate activation when a Mg<sup>2+<\/sup> ion plug is replaced by a Ca<sup>2+ <\/sup>ion.&nbsp; The NMDA glutamate channel has a magnesium block.<\/p>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color\">Experimental magnesium deficiency induces hyperalgesia, which is reversed by NMDA receptor antagonists.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1573046\/\" target=\"_blank\" rel=\"noreferrer noopener\"><img loading=\"lazy\" src=\"http:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/Role-of-spinal-NMDA-1024x576.png\" alt=\"\" class=\"wp-image-1230\" width=\"512\" height=\"288\" srcset=\"https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/Role-of-spinal-NMDA-1024x576.png 1024w, https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/Role-of-spinal-NMDA-300x169.png 300w, https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/Role-of-spinal-NMDA-768x432.png 768w, https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/Role-of-spinal-NMDA-730x410.png 730w, https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/Role-of-spinal-NMDA.png 1152w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/><\/a><\/figure><\/div>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color\">Magnesium supplementation has been shown to reduce post-operative pain and its addition to anaesthetics reduces anaesthesia requirements.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><a href=\"https:\/\/bjanaesthesia.org\/article\/S0007-0912(17)37062-9\/fulltext\" target=\"_blank\" rel=\"noreferrer noopener\"><img loading=\"lazy\" src=\"http:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image-1024x576.png\" alt=\"\" class=\"wp-image-1238\" width=\"512\" height=\"288\" srcset=\"https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image-1024x576.png 1024w, https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image-300x169.png 300w, https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image-768x432.png 768w, https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image-730x410.png 730w, https:\/\/ibshypo.com\/wp-content\/uploads\/2019\/04\/image.png 1152w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/><\/a><\/figure><\/div>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color\">Magnesium deficiency leads to NMDA receptor mediated hyperalgesia and hence enhanced sensitivity to chronic pain and to visceral pain.&nbsp; Magnesium deficiency has been found in <a rel=\"noreferrer noopener\" aria-label=\"IBS patients: (opens in a new tab)\" href=\"https:\/\/jamanetwork.com\/journals\/jama\/article-abstract\/399549\" target=\"_blank\">IBS patients <\/a>and in <a rel=\"noreferrer noopener\" aria-label=\"and in Fibromyalgia patients: (opens in a new tab)\" href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.3109\/13590849409034552\" target=\"_blank\">Fibromyalgia patients.<\/a><\/p>\n\n\n\n<p class=\"has-background has-light-green-cyan-background-color\">We have shown that magnesium deficiency leads to abnormal smooth muscle contraction and visceral hyperalgesia, the two necessary and sufficient conditions in <a rel=\"noreferrer noopener\" aria-label=\"A Fundamental View of IBS (opens in a new tab)\" href=\"http:\/\/ibshypo.com\/index.php\/a-fundamental-view-of-ibs\/\" target=\"_blank\">A Fundamental View of IBS<\/a>.<\/p>\n\n\n\n<p class=\"has-background has-very-light-gray-background-color\">Before addressing the causes of magnesium deficiency we detail some <a href=\"http:\/\/ibshypo.com\/index.php\/circumstantial-evidence\/\">Circumstantial Evidence of Mg Deficiency<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Magnesium plays a central role in the activation of NMDA receptors.&nbsp; NMDA receptors are triggered after prolonged glutamate activation when a Mg2+ ion plug is replaced by a Ca2+ ion.&nbsp; The NMDA glutamate channel has a magnesium block. Experimental magnesium deficiency induces hyperalgesia, which is reversed by NMDA receptor antagonists. Magnesium supplementation has been shown [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/pages\/149"}],"collection":[{"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/comments?post=149"}],"version-history":[{"count":46,"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/pages\/149\/revisions"}],"predecessor-version":[{"id":1547,"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/pages\/149\/revisions\/1547"}],"wp:attachment":[{"href":"https:\/\/ibshypo.com\/index.php\/wp-json\/wp\/v2\/media?parent=149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}